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Using genome-wide association, we identify common variants at 2p12-p13, 6q26, 17q23 and 19q13 associated with serum creatinine, a marker of kidney function (P = 10(-10) to 10(-15)). Of these, rs10206899 (near NAT8, 2p12-p13) and rs4805834 (near SLC7A9, 19q13) were also associated with chronic kidney disease (P = 5.0 x 10(-5) and P = 3.6 x 10(-4), respectively). Our findings provide insight into metabolic, solute and drug-transport pathways underlying susceptibility to chronic kidney disease.

Original publication

DOI

10.1038/ng.566

Type

Journal article

Journal

Nat Genet

Publication Date

05/2010

Volume

42

Pages

373 - 375

Keywords

Biological Transport, Creatinine, Cystatin C, Europe, Gene Expression Regulation, Genetic Markers, Genetic Predisposition to Disease, Genetic Variation, Genome-Wide Association Study, Genotype, Glomerular Filtration Rate, Humans, Kidney, Kidney Failure, Chronic, Models, Genetic