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We studied genes involved in pancreatic beta cell function and survival, identifying associations between SNPs in WFS1 and diabetes risk in UK populations that we replicated in an Ashkenazi population and in additional UK studies. In a pooled analysis comprising 9,533 cases and 11,389 controls, SNPs in WFS1 were strongly associated with diabetes risk. Rare mutations in WFS1 cause Wolfram syndrome; using a gene-centric approach, we show that variation in WFS1 also predisposes to common type 2 diabetes.

Original publication

DOI

10.1038/ng2067

Type

Journal article

Journal

Nat Genet

Publication Date

08/2007

Volume

39

Pages

951 - 953

Keywords

Case-Control Studies, Diabetes Mellitus, Type 2, Genetic Predisposition to Disease, Humans, Insulin-Secreting Cells, Membrane Proteins, Polymorphism, Single Nucleotide