Common variants in WFS1 confer risk of type 2 diabetes.
Sandhu MS., Weedon MN., Fawcett KA., Wasson J., Debenham SL., Daly A., Lango H., Frayling TM., Neumann RJ., Sherva R., Blech I., Pharoah PD., Palmer CNA., Kimber C., Tavendale R., Morris AD., McCarthy MI., Walker M., Hitman G., Glaser B., Permutt MA., Hattersley AT., Wareham NJ., Barroso I.
We studied genes involved in pancreatic beta cell function and survival, identifying associations between SNPs in WFS1 and diabetes risk in UK populations that we replicated in an Ashkenazi population and in additional UK studies. In a pooled analysis comprising 9,533 cases and 11,389 controls, SNPs in WFS1 were strongly associated with diabetes risk. Rare mutations in WFS1 cause Wolfram syndrome; using a gene-centric approach, we show that variation in WFS1 also predisposes to common type 2 diabetes.