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OBJECTIVES:To determine the prevalence of CVD and to identify and characterize associated risk factors in three distinct Eskimo populations. STUDY DESIGN:Cross-sectional. METHODS:A slightly modified Strong Heart Study protocol was followed to examine 454 participants, aged 25-91, from four villages. RESULTS:Overall, 6% of the participants under 55 years of age and 26% of those > or = 55 years of age showed evidence of CHD by ECG, or in patient records. The prevalence of "definite coronary heart disease" (CHD) in women with glucose intolerance (GI) was 21.0%, compared to 2.4% in those with normal glucose tolerance (NGT). Men had comparable values of 26.7% and 6.3%. In addition, comparable values for "possible CHD" were 29.7% vs 6.0% for women and 21.4% vs 8.0% for men. GI was associated with relatively higher prevalences of CHD in women than in men (prevalence ratio = 8.5 vs 4.3). CHD was significantly related to age, glucose intolerance and insulin. Hypertension and obesity were significantly associated with CHD only in some ethnic groups. The prevalence of current smokers was 56%. CONCLUSIONS:Recent changes in lifestyle and diet of Alaskan Eskimos, leading to obesity, hypertension, insulin resistance and DM, contribute to an increased risk for cardiovascular disease.

Original publication

DOI

10.3402/ijch.v64i4.18014

Type

Journal article

Journal

International journal of circumpolar health

Publication Date

09/2005

Volume

64

Pages

365 - 386

Addresses

Department of Neurological Surgery, University of Virginia, Charlottesville 22908-0212, USA. se6b@virginia.edu

Keywords

Humans, Albuminuria, Cardiovascular Diseases, Hypertension, Obesity, Insulin, Lipids, Body Mass Index, Waist-Hip Ratio, Prevalence, Logistic Models, Risk Factors, Cross-Sectional Studies, Smoking, Life Style, Comorbidity, Age Distribution, Sex Distribution, Adult, Aged, Aged, 80 and over, Middle Aged, Inuits, Alaska, Female, Male, Glycated Hemoglobin A