Cookies on this website
We use cookies to ensure that we give you the best experience on our website. If you click 'Continue' we'll assume that you are happy to receive all cookies and you won't see this message again. Click 'Find out more' for information on how to change your cookie settings.

Over the past year, vertebrate GATA factors have been found to participate directly in several signal-transduction pathways. Smad3, phosphorylated by TGF-beta signalling, interacts with GATA3 to induce differentiation of T helper cells. Hypertrophic stimuli act through RhoA GTPase and ROCK kinase to activate GATA4 in cardiac myocytes. In the liver, GATA4 is elevated by BMP and FGF signalling, and is able to bind to chromatin targets. Invertebrate GATA factors play a central role in specifying the mesendoderm.

Type

Journal article

Journal

Curr Opin Genet Dev

Publication Date

08/2002

Volume

12

Pages

416 - 422

Keywords

Animals, Biological Evolution, DNA-Binding Proteins, Drosophila, Endoderm, Invertebrates, Mesoderm, Multigene Family, Muscle, Smooth, Myocardium, Vertebrates