Cookies on this website
We use cookies to ensure that we give you the best experience on our website. If you click 'Continue' we'll assume that you are happy to receive all cookies and you won't see this message again. Click 'Find out more' for information on how to change your cookie settings.

There is a pressing need for robust imaging markers to assist in the development of drugs for the treatment of atherosclerosis. Conventional imaging methods provide quantitative and morphological data but may be inadequate for assessing a new generation of therapies that modify plaque biology directly. Here, we compare the main imaging modalities used to image atherosclerosis in the clinical-trial setting, and assess their ability to predict clinical outcomes for a given sample size. We consider how emerging molecular and cellular imaging techniques could offer the possibility to quantify changes in biological function at the level of the plaque, even without gross structural change.

Original publication

DOI

10.1038/nrd2588

Type

Journal article

Journal

Nat Rev Drug Discov

Publication Date

06/2008

Volume

7

Pages

517 - 529

Keywords

Atherosclerosis, Carotid Arteries, Clinical Trials as Topic, Coronary Vessels, Diagnostic Imaging, Drug Design, Humans, Hypolipidemic Agents