Cookies on this website
We use cookies to ensure that we give you the best experience on our website. If you click 'Continue' we'll assume that you are happy to receive all cookies and you won't see this message again. Click 'Find out more' for information on how to change your cookie settings.

Common sequence variants situated between the HBS1L and MYB genes on chromosome 6q23.3 (HMIP) influence the proportion of F cells (erythrocytes that carry measurable amounts of fetal hemoglobin). Since the physiological processes underlying the F-cell variability are thought to be linked to kinetics of erythrocyte maturation and differentiation, we have investigated the influence of the HMIP locus on other hematologic parameters. Here we show a significant impact of HMIP variability on several types of peripheral blood cells: erythrocyte, platelet, and monocyte counts as well as erythrocyte volume and hemoglobin content in healthy individuals of European ancestry. These results support the notion that changes of F-cell abundance can be an indicator of more general shifts in hematopoietic patterns in humans.

Original publication

DOI

10.1182/blood-2007-05-093419

Type

Journal article

Journal

Blood

Publication Date

15/11/2007

Volume

110

Pages

3624 - 3626

Keywords

Blood Cell Count, Blood Platelets, Chromosomes, Human, Pair 6, DNA, Intergenic, Erythrocytes, Female, Genes, myb, Humans, Male, Monocytes, Peptide Elongation Factor 1, Polymorphism, Single Nucleotide