Cookies on this website
We use cookies to ensure that we give you the best experience on our website. If you click 'Continue' we'll assume that you are happy to receive all cookies and you won't see this message again. Click 'Find out more' for information on how to change your cookie settings.

Family history is an important independent risk factor for coronary artery disease (CAD), and identification of susceptibility genes for this common, complex disease is a vital goal. Although there has been considerable success in identifying genetic variants that influence well-known risk factors, such as cholesterol levels, progress in unearthing novel CAD genes has been slow. However, advances are now being made through the application of large-scale, systematic, genome-wide approaches. Recent findings particularly highlight the link between CAD and inflammation and immunity, and highlight the biological insights to be gained from a genetic understanding of the world's biggest killer.

Original publication

DOI

10.1038/nrg1805

Type

Journal article

Journal

Nat Rev Genet

Publication Date

03/2006

Volume

7

Pages

163 - 173

Keywords

Animals, Coronary Artery Disease, Genetic Predisposition to Disease, Genetic Variation, Genome, Human, Humans, Inflammation, Sequence Analysis, DNA