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The pace of research into the lymphatic system continues to accelerate with the availability of new molecular markers. One such marker, LYVE-1, the lymphatic receptor for the extracellular matrix mucopolysaccharide hyaluronan, has been a key component of many important studies on embryonic and tumour-induced lymphangiogenesis, and continues to be used for the detection and isolation of lymphatic endothelial cells. However, LYVE-1 is interesting in its own right. Being a member of the Link protein family whose only other major hyaluronan receptor is directly involved in leukocyte migration and tumour metastasis, LYVE-1 is already implicated in the trafficking of cells within lymphatic vessels and lymph nodes. The current challenge is to determine the precise roles played by LYVE-1 and other scavenger type receptors in the immune functions of the lymphatics as well as to use LYVE-1 and other markers to investigate the way in which tumours exploit lymphatic vessels for metastasis.

Original publication

DOI

10.1111/j.1600-0463.2004.apm11207-0811.x

Type

Journal article

Journal

APMIS

Publication Date

07/2004

Volume

112

Pages

526 - 538

Keywords

Amino Acid Sequence, Animals, Biomarkers, Cell Movement, Glycoproteins, Humans, Hyaluronan Receptors, Hyaluronic Acid, Lymphangiogenesis, Lymphatic Vessels, Molecular Sequence Data, Neoplasm Metastasis, Vesicular Transport Proteins