Kerr-Cai Group - Epigenetic regulation of cholangiocarcinoma growth
- David Kerr, Shijie Cai
about the research
Cholangiocarcinoma (CCA) is a rare malignant bile duct tumour with an average incidence of 1/100,000 in the population per year. The overall incidence of CAA includes 15% of primary liver cancers, the second most common type of primary liver cancer. The majority of which are inoperable and resistant to chemotherapy; at present the 5-year survival rate is less than 5%. Therefore, there is an urgent need to identify novel molecule mechanisms that drive this malignancy and to facilitate the development of targeted therapies.
We have recently investigated the role of ubiquitin specific peptidase (USP) molecules in CCA growth. We demonstrated that USP rewired the tumour development programme by modifying oncogenes and the tumour survival signalling pathways. Essentially, epigenetic modulation plays a crucial role in regulating the progression of CCA, maintaining oncoprotein histone structures to prevent tumour cell from apoptosis and sustain the cell survival.
To unravel mechanisms by which USP epigenetically determine CCA growth, the approaches of epigenetic chemical probes, the CRISPR library screening, and artificial intelligent will be employed for this study. Outcomes of these investigations will enable us to identify biomarkers and drugs for CCA therapy.
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