Homozygous hypomorphic HNF1A alleles are a novel cause of young-onset diabetes and result in sulphonylurea sensitive diabetes
Journal article
GLOYN A. et al, (2020), Diabetes Care
Loss of ZnT8 function protects against diabetes by enhanced insulin secretion.
Journal article
Dwivedi OP. et al, (2019), Nat Genet
A CRISPR/Cas9 genome editing pipeline in the EndoC-βH1 cell line to study genes implicated in beta cell function
Journal article
Grotz A. et al, (2019)
Deep learning models predict regulatory variants in pancreatic islets and refine type 2 diabetes association signals
Journal article
Wesolowska-Andersen A. et al, (2019)
Exocrine or endocrine? A circulating pancreatic elastase that regulates glucose homeostasis
Journal article
Gloyn AL., (2019), Nature Metabolism, 1, 853 - 855
Translational genomics and precision medicine: Moving from the lab to the clinic.
Journal article
Zeggini E. et al, (2019), Science (New York, N.Y.), 365, 1409 - 1413
Investigating a Candidate Causal Allele in Type 2 Diabetes Susceptibility Gene PAM as a Cause of Neonatal Diabetes Mellitus
Conference paper
Sengupta S. et al, (2019), DIABETES, 68
Developing a network view of type 2 diabetes risk pathways through integration of genetic, genomic and functional data.
Journal article
Fernández-Tajes J. et al, (2019), Genome Med, 11
Fostering improved human islet research: a European perspective
Journal article
Marchetti P. et al, (2019), Diabetologia
Plasma Fucosylated Glycans and C-Reactive Protein as Biomarkers of HNF1A-MODY in Young Adult-Onset Nonautoimmune Diabetes.
Journal article
Juszczak A. et al, (2019), Diabetes Care, 42, 17 - 26
Electrophysiological properties of human beta-cell lines EndoC-βH1 and -βH2 conform with human beta-cells.
Journal article
Hastoy B. et al, (2018), Sci Rep, 8
Fine-mapping type 2 diabetes loci to single-variant resolution using high-density imputation and islet-specific epigenome maps.
Journal article
Mahajan A. et al, (2018), Nat Genet, 50, 1505 - 1513
Precision medicine in the management of type 2 diabetes.
Journal article
Gloyn AL. and Drucker DJ., (2018), Lancet Diabetes Endocrinol, 6, 891 - 900
Loss of ZnT8 function protects against diabetes by enhanced insulin secretion
Journal article
Dwivedi OP. et al, (2018)
Author Correction: Regulatory variants at KLF14 influence type 2 diabetes risk via a female-specific effect on adipocyte size and body composition.
Journal article
Small KS. et al, (2018), Nat Genet, 50
Understanding human fetal pancreas development using subpopulation sorting, RNA sequencing and single-cell profiling.
Journal article
Ramond C. et al, (2018), Development, 145
Type 2 diabetes risk alleles in PAM impact insulin release from human pancreatic β-cells.
Journal article
Thomsen SK. et al, (2018), Nat Genet, 50, 1122 - 1131
Patterns of differential gene expression in a cellular model of human islet development, and relationship to type 2 diabetes predisposition.
Journal article
Perez-Alcantara M. et al, (2018), Diabetologia, 61, 1614 - 1622
Developing a network view of type 2 diabetes risk pathways through integration of genetic, genomic and functional data
Journal article
Fernéndez-Tajes J. et al, (2018)
Maturity onset diabetes of the young due to HNF1A variants in Croatia.
Journal article
Pavić T. et al, (2018), Biochem Med (Zagreb), 28