Aim: The novel hydrogel systems made from sodium alginate, pectin, beta-cyclodextrin and deoxycholic acid (DCA) were proposed as potential drug-delivery matrices. Materials & methods: To ensure biocompatibility, rheological parameters were examined and hydrogels' effects on bioenergetic parameters and cellular viability on murine hepatic, and muscle and pancreatic beta cells. Results & conclusion: All hydrogels show non-Newtonian, shear thinning behavior. Cells displayed various oxygen-dependent viability patterns, with the bile acid overall adversely affecting their biological activities. All cells performed best under normoxia, with pancreatic beta cells displaying the most profound oxygen-dependent viability behavior. The cells tolerated the addition of a moderate concentration of beta-cyclodextrin to the polymer matrix.
Journal article
2024-02-01T00:00:00+00:00
15
119 - 134
15
beta cyclodextrin, bile acid, biocompatibility, deoxycholic acid, hydrogel, mitochondrial respiration, Mice, Animals, Cyclodextrins, Bile Acids and Salts, beta-Cyclodextrins, Hydrogels, Oxygen