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Polymyositis (PM) appears with indolent proximal muscle weakness and is an inflammatory disease with breakdown of muscle cells. In our study the protein charge concentrations of the contractile proteins in the A and I bands were determined, applying a microelectrode technique. Patients with PM show a lower protein charge concentration than healthy control subjects which may be caused by the breakdown and removal of the proteins in the contractile filaments. A tool to judge the state of the disease as well as an aid in diagnosis may have been found in this method.

Type

Journal article

Journal

J Rheumatol

Publication Date

12/1989

Volume

16

Pages

1542 - 1544

Keywords

Electrophysiology, Humans, Muscle Proteins, Myositis, Reference Values