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Research into two of the four classes of naturally produced beta-lactams--the clavams and carbapenems--has started to throw light upon their biochemical pathways and underlying genetics. Interesting similarities between these two classes, from their joint discovery to an apparently common beta-lactam ring-forming enzyme, are now being revealed.


Journal article


Trends Microbiol

Publication Date





203 - 208


Anti-Bacterial Agents, Carbapenems, Clavulanic Acids, beta-Lactams