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Smoking and demographic variables are known to be risk factors for the development of thyroid-associated orbitopathy (TAO) among patients with Graves' hyperthyroidism, but a firm genetic basis for TAO has not been established. We show that the presence and severity of TAO are associated with an allele of the cytotoxic T lymphocyte antigen-4-gene.

Original publication

DOI

10.1016/S0140-6736(99)01465-8

Type

Journal article

Journal

Lancet

Publication Date

28/08/1999

Volume

354

Pages

743 - 744

Keywords

Abatacept, Adolescent, Adult, Aged, Aged, 80 and over, Alleles, Antigens, CD, Antigens, Differentiation, CTLA-4 Antigen, Child, Female, Genetic Markers, Genetic Predisposition to Disease, Graves Disease, Humans, Immunoconjugates, Male, Middle Aged, Polymorphism, Genetic, Risk Factors, T-Lymphocytes, Cytotoxic