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We describe the long-term survival of an individual infected with HIV-1 during extrauterine life as a premature newborn. In the absence of viral attenuation in the Nef/LTR structure or significant co-receptor polymorphisms, slow progression was associated with the strong HIV-1-specific broadly cross-reactive CD8 T cell responses. HIV-1 infection as early as 25 weeks' gestation may thus results in the development of immune responses that control viral replication and lead to prolonged survival.

Type

Journal article

Journal

AIDS

Publication Date

18/10/2002

Volume

16

Pages

2085 - 2087

Keywords

Adolescent, Amino Acid Sequence, CD8-Positive T-Lymphocytes, Female, Gene Products, nef, HIV Infections, HIV Long Terminal Repeat, HIV Long-Term Survivors, HIV-1, Humans, Infant, Newborn, Infant, Premature, Diseases, Molecular Sequence Data, nef Gene Products, Human Immunodeficiency Virus