Cookies on this website
We use cookies to ensure that we give you the best experience on our website. If you click 'Continue' we'll assume that you are happy to receive all cookies and you won't see this message again. Click 'Find out more' for information on how to change your cookie settings.

Heart failure is one of the paramount global causes of morbidity and mortality. Despite this pandemic need, the available clinical counter-measures have not altered substantially in recent decades, most notably in the context of pharmacological interventions. Cell death plays a causal role in heart failure, and its inhibition poses a promising approach that has not been thoroughly explored. In previous approaches to target discovery, clinical failures have reflected a deficiency in mechanistic understanding, and in some instances, failure to systematically translate laboratory findings toward the clinic. Here, we review diverse mouse models of heart failure, with an emphasis on those that identify potential targets for pharmacological inhibition of cell death, and on how their translation into effective therapies might be improved in the future.

Original publication

DOI

10.1016/B978-0-12-397920-9.00002-0

Type

Journal article

Journal

Curr Top Dev Biol

Publication Date

2014

Volume

109

Pages

171 - 247

Keywords

Apoptosis, Cell death, Drug discovery, Heart failure, Mouse models, Protein kinases, Animals, Apoptosis, Autophagy, Cell Communication, Cell Survival, Disease Models, Animal, Drug Discovery, Heart Failure, Mice, Models, Cardiovascular, Necrosis, Protein Kinases, Signal Transduction