Genome-wide association identifies a susceptibility locus for coronary artery disease in the Chinese Han population.
Wang F., Xu C-Q., He Q., Cai J-P., Li X-C., Wang D., Xiong X., Liao Y-H., Zeng Q-T., Yang Y-Z., Cheng X., Li C., Yang R., Wang C-C., Wu G., Lu Q-L., Bai Y., Huang Y-F., Yin D., Yang Q., Wang X-J., Dai D-P., Zhang R-F., Wan J., Ren J-H., Li S-S., Zhao Y-Y., Fu F-F., Huang Y., Li Q-X., Shi S-W., Lin N., Pan Z-W., Li Y., Yu B., Wu Y-X., Ke Y-H., Lei J., Wang N., Luo C-Y., Ji L-Y., Gao L-J., Li L., Liu H., Huang E-W., Cui J., Jia N., Ren X., Li H., Ke T., Zhang X-Q., Liu J-Y., Liu M-G., Xia H., Yang B., Shi L-S., Xia Y-L., Tu X., Wang QK.
Coronary artery disease (CAD) causes more than 700,000 deaths each year in China. Previous genome-wide association studies (GWAS) in populations of European ancestry identified several genetic loci for CAD, but no such study has yet been reported in the Chinese population. Here we report a three-stage GWAS in the Chinese Han population. We identified a new association between rs6903956 in a putative gene denoted as C6orf105 on chromosome 6p24.1 and CAD (P = 5.00 × 10⁻³, stage 2 validation; P = 3.00 × 10⁻³, P = 1.19 × 10⁻⁸ and P = 4.00 × 10⁻³ in three independent stage 3 replication populations; P = 4.87 × 10⁻¹², odds ratio = 1.51 in the combined population). The minor risk allele A of rs6903956 is associated with decreased C6orf105 mRNA expression. We report the first GWAS for CAD in the Chinese Han population and identify a SNP, rs6903956, in C6orf105 associated with susceptibility to CAD in this population.