Genome-wide association identifies a susceptibility locus for coronary artery disease in the Chinese Han population.
Wang F., Xu CQ., He Q., Cai JP., Li XC., Wang D., Xiong X., Liao YH., Zeng QT., Yang YZ., Cheng X., Li C., Yang R., Wang CC., Wu G., Lu QL., Bai Y., Huang YF., Yin D., Yang Q., Wang XJ., Dai DP., Zhang RF., Wan J., Ren JH., Li SS., Zhao YY., Fu FF., Huang Y., Li QX., Shi SW., Lin N., Pan ZW., Li Y., Yu B., Wu YX., Ke YH., Lei J., Wang N., Luo CY., Ji LY., Gao LJ., Li L., Liu H., Huang EW., Cui J., Jia N., Ren X., Li H., Ke T., Zhang XQ., Liu JY., Liu MG., Xia H., Yang B., Shi LS., Xia YL., Tu X., Wang QK.
Coronary artery disease (CAD) causes more than 700,000 deaths each year in China. Previous genome-wide association studies (GWAS) in populations of European ancestry identified several genetic loci for CAD, but no such study has yet been reported in the Chinese population. Here we report a three-stage GWAS in the Chinese Han population. We identified a new association between rs6903956 in a putative gene denoted as C6orf105 on chromosome 6p24.1 and CAD (P = 5.00 × 10⁻³, stage 2 validation; P = 3.00 × 10⁻³, P = 1.19 × 10⁻⁸ and P = 4.00 × 10⁻³ in three independent stage 3 replication populations; P = 4.87 × 10⁻¹², odds ratio = 1.51 in the combined population). The minor risk allele A of rs6903956 is associated with decreased C6orf105 mRNA expression. We report the first GWAS for CAD in the Chinese Han population and identify a SNP, rs6903956, in C6orf105 associated with susceptibility to CAD in this population.