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Application of the experimental design of genome-wide association studies (GWASs) is now 10 years old (young), and here we review the remarkable range of discoveries it has facilitated in population and complex-trait genetics, the biology of diseases, and translation toward new therapeutics. We predict the likely discoveries in the next 10 years, when GWASs will be based on millions of samples with array data imputed to a large fully sequenced reference panel and on hundreds of thousands of samples with whole-genome sequencing data.

Original publication

DOI

10.1016/j.ajhg.2017.06.005

Type

Journal article

Journal

Am J Hum Genet

Publication Date

06/07/2017

Volume

101

Pages

5 - 22

Keywords

SNP, auto-immune disease, genome-wide association study, heritability, obesity, schizophrenia, Genetic Pleiotropy, Genetic Predisposition to Disease, Genome-Wide Association Study, Humans, Multifactorial Inheritance, Translational Medical Research