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The aim of present study was to evaluate the potential of mucoadhesive alginate-coated chitosan microparticles (A-CHMp) for oral vaccine against anthrax. The zeta potential of A-CHMp was -29.7 mV, and alginate coating could prevent the burst release of antigen in simulated gastric fluid. The results indicated that A-CHMp was mucoadhesive in nature and transported it to the peyer's patch upon oral delivery. The immunization studies indicated that A-CHMp resulted in the induction of potent systemic and mucosal immune responses, whereas alum-adjuvanted rPA could induce only systemic immune response. Thus, A-CHMp represents a promising acid carrier adjuvant for oral immunization against anthrax.

Original publication

DOI

10.3109/21691401.2013.769447

Type

Journal article

Journal

Artif Cells Nanomed Biotechnol

Publication Date

02/2014

Volume

42

Pages

47 - 57

Keywords

Adjuvants, Immunologic, Administration, Oral, Alginates, Animals, Anthrax, Anthrax Vaccines, Antibodies, Bacterial, Antigens, Bacterial, Bacillus anthracis, Bacterial Toxins, Biomimetic Materials, Chitosan, Female, Gastric Juice, Immunity, Innate, Immunity, Mucosal, Mice, Mice, Inbred BALB C, Neutralization Tests, Peyer's Patches, Vaccination