Resolving TYK2 locus genotype-to-phenotype differences in autoimmunity.

Dendrou CA., Cortes A., Shipman L., Evans HG., Attfield KE., Jostins L., Barber T., Kaur G., Kuttikkatte SB., Leach OA., Desel C., Faergeman SL., Cheeseman J., Neville MJ., Sawcer S., Compston A., Johnson AR., Everett C., Bell JI., Karpe F., Ultsch M., Eigenbrot C., McVean G., Fugger L.

Thousands of genetic variants have been identified, which contribute to the development of complex diseases, but determining how to elucidate their biological consequences for translation into clinical benefit is challenging. Conflicting evidence regarding the functional impact of genetic variants in the tyrosine kinase 2 (TYK2) gene, which is differentially associated with common autoimmune diseases, currently obscures the potential of TYK2 as a therapeutic target. We aimed to resolve this conflict by performing genetic meta-analysis across disorders; subsequent molecular, cellular, in vivo, and structural functional follow-up; and epidemiological studies. Our data revealed a protective homozygous effect that defined a signaling optimum between autoimmunity and immunodeficiency and identified TYK2 as a potential drug target for certain common autoimmune disorders.

DOI

10.1126/scitranslmed.aag1974

Type

Journal article

Journal

Sci Transl Med

Publication Date

02/11/2016

Volume

8

Keywords

Animals, Autoimmune Diseases, Autoimmunity, CD4-Positive T-Lymphocytes, Cytokines, Epigenesis, Genetic, Female, Genetic Association Studies, Genetic Variation, Genomics, Genotype, HEK293 Cells, Homozygote, Humans, Immune System, Janus Kinase 2, Leukocytes, Mononuclear, Male, Mice, Mutation, Missense, Phenotype, Polymorphism, Single Nucleotide, Protein Conformation, Quantitative Trait Loci, Recombination, Genetic, Sequence Analysis, RNA, Signal Transduction, TYK2 Kinase, Transcriptome

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