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Epidemiological studies have shown that human leukocyte antigen (HLA) allelic polymorphisms are closely correlated to susceptibility to nasopharyngeal carcinoma (NPC), and in a previous study, we showed that HLA-B*46 and HLA-A*02-B*46 haplotypes were strongly associated with NPC susceptibility. In this retrospective study, we investigated the phenotype of the HLA-A and HLA-B alleles and haplotypes and correlated these data to the clinical and pathological parameters of NPC to understand the role of HLA alleles and haplotypes in NPC prognosis. The cohort comprised 117 NPC patients from a Han population in Xinjiang. The local recurrence-free survival (LRFS), distant metastasis- free survival (DMFS), disease-free survival (DFS), and overall survival (OS) were analyzed. The 5-year DMFS of the HLA-A*02-B*46 haplotype carriers and non-carriers was 66.4% and 90.3%, respectively. In addition, age was found to be a prognostic factor for LRFS, DFS, and OS (P=0.032, 0.040, and 0.013, respectively). We found that the HLA-A*02-B*46 haplotype might be a prognostic marker in addition to the traditional TNM staging in patients with NPC.

Original publication

DOI

10.1007/s11596-016-1647-y

Type

Journal article

Journal

J Huazhong Univ Sci Technolog Med Sci

Publication Date

10/2016

Volume

36

Pages

700 - 704

Keywords

human leukocyte antigens, metastasis, nasopharyngeal carcinoma, phenotype, prognosis, Adolescent, Adult, Aged, Aged, 80 and over, Biomarkers, Tumor, Child, Disease-Free Survival, Female, HLA-A Antigens, HLA-B Antigens, Haplotypes, Humans, Male, Middle Aged, Nasopharyngeal Neoplasms, Neoplasm Metastasis, Neoplasm Staging, Prognosis, Retrospective Studies