Cookies on this website
We use cookies to ensure that we give you the best experience on our website. If you click 'Continue' we'll assume that you are happy to receive all cookies and you won't see this message again. Click 'Find out more' for information on how to change your cookie settings.

We describe a reference panel of 64,976 human haplotypes at 39,235,157 SNPs constructed using whole-genome sequence data from 20 studies of predominantly European ancestry. Using this resource leads to accurate genotype imputation at minor allele frequencies as low as 0.1% and a large increase in the number of SNPs tested in association studies, and it can help to discover and refine causal loci. We describe remote server resources that allow researchers to carry out imputation and phasing consistently and efficiently.

Original publication

DOI

10.1038/ng.3643

Type

Journal article

Journal

Nat Genet

Publication Date

10/2016

Volume

48

Pages

1279 - 1283

Keywords

Alleles, Genetic Techniques, Genome-Wide Association Study, Genotype, Haplotypes, Humans, Internet, Polymorphism, Single Nucleotide, Reference Values