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An inversion of chromosome 14, inv(14)(q11,q32), is frequently observed in human T cell tumors; the cytogenetic breakpoints are of interest because the T cell receptor alpha-chain and immunoglobulin heavy chain genes reside on chromosome bands 14q11 and 14q32, respectively. We have investigated the structure of the alpha-chain genes in a T cell line harboring the chromosome 14 inversion. On the normal chromosome 14, a V alpha segment has rearranged nonproductively with a J alpha segment. In contrast, the inverted chromosome features an unprecedented rearrangement in which an immunoglobulin heavy chain variable gene segment (VH) on chromosome band 14q32 has joined with a J alpha segment from band 14q11. The VH-J alpha C alpha rearrangement is productive at the genomic level and therefore may encode a hybrid immunoglobulin/T cell receptor polypeptide.

Type

Journal article

Journal

Cell

Publication Date

12/1985

Volume

43

Pages

705 - 713

Keywords

Alleles, Base Sequence, Cell Line, Chromosome Inversion, Chromosomes, Human, 13-15, Humans, Immunoglobulin Heavy Chains, Immunoglobulin J-Chains, Immunoglobulin Variable Region, Lymphoma, Receptors, Antigen, T-Cell, T-Lymphocytes