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Cosmid clones containing the human gamma, epsilon and alpha heavy chain constant region genes and an epsilon pseudogene have been isolated. All these genes have a switch sequence detectable by hybridization. We have studied overlapping cosmids covering two separate regions of the genome, and the gene order in each of these regions was found to be gamma-gamma-epsilon-alpha. This implies an evolutionary duplication in this multigene family involving gamma, epsilon and alpha genes.

Type

Journal article

Journal

Nature

Publication Date

23/12/1982

Volume

300

Pages

709 - 713

Keywords

Biological Evolution, Chromosome Mapping, Cloning, Molecular, Humans, Immunoglobulin Constant Regions, Immunoglobulin Heavy Chains, Immunoglobulin alpha-Chains, Immunoglobulin epsilon-Chains, Immunoglobulin gamma-Chains, Immunoglobulins