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Recombinant DNA clones have been used to directly demonstrate that the Burkitt lymphoma cell line Raji, t(8;14) (q24;q32), has a rearranged copy of the c-myc gene adjacent to the gamma 1 constant region gene of the human immunoglobulin heavy-chain locus; the genes are arranged in the opposite direction for transcription. At least one further 5' exon has been detected in the normal c-myc gene by analysis of RNA transcripts, and the occurrence of high levels of two c-myc mRNA size classes, both apparently initiating in this exon, is described.

Type

Journal article

Journal

Nature

Publication Date

14/07/1983

Volume

304

Pages

135 - 139

Keywords

Burkitt Lymphoma, Cell Line, Chromosome Mapping, Cloning, Molecular, DNA Restriction Enzymes, DNA, Recombinant, Humans, Immunoglobulin Heavy Chains, Immunoglobulin gamma-Chains, Oncogenes, Transcription, Genetic, Translocation, Genetic