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Mitogenically stimulated human and mouse lymphocytes enter the cell cycle (G0, G1A, G1B, S, G2+M) via a newly recognized subphase, G1'. This subphase precedes G1A and is distinct from G0. The G1' subphase is absent in immortalized and tumorigenic lymphoblastoid cell lines (LCLs) by cytofluorimetric criteria. Furthermore, colcemid inhibits transition through the G0/G1' as well as G2 phases in mitogen-stimulated lymphocytes and in LCLs. Tumorigenic LCLs are not sensitive to growth inhibition by colcemid during early G1. These observations suggest that a progressive series of changes have occurred during G0/G1' which lead to deregulation of growth control.

Type

Journal article

Journal

Exp Cell Res

Publication Date

11/1986

Volume

167

Pages

241 - 251

Keywords

Animals, Cell Line, Cell Transformation, Neoplastic, Cell Transformation, Viral, Demecolcine, Humans, Interphase, Lymphocyte Activation, Lymphocytes, Mice