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The 3' terminal nucleotide sequence of two clones containing DNA complementary to mu chain mRNA of IgM-secreting cells has been determined. The sequence shows a termination codon (UGA) adjacent to the terminal tyrosine codon for the secreted protein and a 3' non-coding region of at least 106 bases. The primary translation product of this mu chain mRNA seems to terminate at the tyrosine of the secreted protein.

Type

Journal article

Journal

Nucleic Acids Res

Publication Date

25/02/1980

Volume

8

Pages

703 - 713

Keywords

Animals, Base Sequence, Cloning, Molecular, Codon, DNA, Recombinant, Immunoglobulin Heavy Chains, Immunoglobulin M, Immunoglobulin mu-Chains, Mice, Peptide Chain Termination, Translational, RNA, Messenger