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We have examined the chromosomal location of human T cell-specific genes which are involved in antigen recognition and of a gene which specifically rearranges in T cells. The genes encoding both the variable and constant region segments of the T cell receptor alpha chain are found on chromosome 14 while the delta chain gene of the T cell receptor-associated T3 complex is localised to chromosome 11. Further, the two tandemly arranged T cell-specific rearranging genes, designated gamma, were mapped to chromosome 7, but apparently not closely linked to the previously mapped T cell receptor beta-chain gene. The locations of the three different genes, which undergo rearrangement in T cells, may correlate with the chromosomal breakpoints known to be involved in translocations within abnormal human T cells.

Type

Journal article

Journal

EMBO J

Publication Date

06/1985

Volume

4

Pages

1461 - 1465

Keywords

Base Sequence, Chromosome Mapping, Chromosomes, Human, 13-15, Chromosomes, Human, 6-12 and X, Humans, Leukemia, Receptors, Antigen, T-Cell, T-Lymphocytes, Translocation, Genetic