Cookies on this website
We use cookies to ensure that we give you the best experience on our website. If you click 'Continue' we'll assume that you are happy to receive all cookies and you won't see this message again. Click 'Find out more' for information on how to change your cookie settings.

Somatic cell hybrids containing chromosomes from a patient with chronic myeloid leukaemia were used as a source of DNA for filter hybridizations with immunoglobulin lambda light chain constant region and c-onc probes. The results show that at least part of the human lambda constant region locus remains on the abnormal chromosome 22 (the Philadelphia chromosome) and therefore that this translocation occurs distal to these genes. Further, in the patient studied the c-abl gene has been translocated to the abnormal chromosome 22, thus creating a new genetic linkage between C lambda and c-abl genes.

Type

Journal article

Journal

Mol Biol Med

Publication Date

07/1983

Volume

1

Pages

11 - 19

Keywords

Animals, Chromosome Aberrations, Chromosome Disorders, Chromosomes, Human, 21-22 and Y, Cricetinae, Cricetulus, DNA, Neoplasm, Humans, Hybrid Cells, Immunoglobulin Light Chains, Immunoglobulin lambda-Chains, Leukemia, Myeloid, Nucleic Acid Hybridization, Translocation, Genetic