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A common chromosomal abnormality in childhood T-cell acute leukemia is a translocation, t(10;14) (q24;q11), that together with the variant t(7;10)(q35;q24) is present in up to 7% of this tumor type. The gene adjacent to the 10q24 region is transcriptionally activated after translocation to either TCRD (14q11) or TCRB (7q35). It encodes a homeobox gene closely related to the developmentally regulated homeotic genes of flies and mammals. The coding capacity of this activated gene, designated HOX11, is undisturbed in a T-cell line carrying the translocation t(7;10)(q35;q24). Therefore, the HOX11 homeobox gene seems to be involved in T-cell tumorigenesis.

Type

Journal article

Journal

Proc Natl Acad Sci U S A

Publication Date

15/10/1991

Volume

88

Pages

8900 - 8904

Keywords

Amino Acid Sequence, Animals, Cell Line, Chromosome Banding, Chromosomes, Human, Pair 10, Chromosomes, Human, Pair 7, DNA, Neoplasm, DNA-Binding Proteins, Genes, Homeobox, Homeodomain Proteins, Humans, Introns, Leukemia-Lymphoma, Adult T-Cell, Mice, Molecular Sequence Data, Oncogene Proteins, Oncogenes, Proto-Oncogene Proteins, Receptors, Antigen, T-Cell, alpha-beta, Receptors, Antigen, T-Cell, gamma-delta, Restriction Mapping, Sequence Homology, Nucleic Acid, T-Lymphocytes, Translocation, Genetic