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A translocation involving human chromosome 10, band q24, in a subset of T-cell acute leukemias disrupts a region surrounding the putative oncogene HOX11, which encodes a protein with a homeodomain. The HOX11 protein binds to a specific DNA sequence, it localizes to the cell nucleus, and it transactivates transcription of a reporter gene linked to a cis-regulatory element, suggesting that HOX11 functions in vivo as a positive transcription activator. PCR analysis shows that the HOX11 homeodomain is a member of a distinct class of homeodomains, representatives of which occur in murine and Drosophila genomes. These all contain a threonine residue in place of the more common isoleucine or valine in helix 3 of the homeodomain. HOX11 therefore appears to belong to a family of DNA-binding transactivators of transcription.

Type

Journal article

Journal

Proc Natl Acad Sci U S A

Publication Date

15/05/1993

Volume

90

Pages

4431 - 4435

Keywords

Amino Acid Sequence, Animals, Base Sequence, Binding Sites, Cell Nucleus, Consensus Sequence, DNA-Binding Proteins, Genes, Homeobox, Genes, Insect, Homeodomain Proteins, Humans, Mice, Molecular Sequence Data, Multigene Family, Mutagenesis, Site-Directed, Nuclear Proteins, Oligodeoxyribonucleotides, Oncogene Proteins, Proto-Oncogene Proteins, Recombinant Proteins, Structure-Activity Relationship, Transcription Factors, Transcriptional Activation, Transfection