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An important new family of proteins has recently been described that carries a novel cysteine-rich zinc-binding domain called the LIM domain. This protein family is present in mammals, amphibians, flies, worms and plants and its main function is in developmental regulation. Although a role in protein-protein interaction seems likely, intriguing similarities to GATA zinc fingers imply that the LIM domain may also be involved in binding to specific nucleic acids.


Journal article


Trends Genet

Publication Date





315 - 320


Amino Acid Sequence, DNA-Binding Proteins, Molecular Sequence Data, Protein Binding, Proteins, Sequence Homology, Amino Acid, Zinc Fingers