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The LIM-only protein Lmo2, originally identified as an oncogenic protein in human T cell leukemia, is essential for erythropoiesis. A possible role for Lmo2 in transcription during erythropoiesis has been investigated. Direct interaction of Lmo2 was observed in vitro and in vivo with the zinc finger transcription factor GATA-1, as well as with the basic helix-loop-helix (bHLH) transcription factor Tall. By using mammalian two-hybrid analysis, E47/Tall/Lmo2/GATA-1 protein complex could be demonstrated. Thus, a molecular link exists between three proteins crucial for erythropoiesis. This data suggest that variations in amounts of complexes involving Lmo2, Tall, and GATA-1 could be important for erythroid differentiation.

Type

Journal article

Journal

Leukemia

Publication Date

04/1997

Volume

11 Suppl 3

Pages

307 - 312

Keywords

Adaptor Proteins, Signal Transducing, Animals, Basic Helix-Loop-Helix Transcription Factors, COS Cells, DNA-Binding Proteins, Erythroid-Specific DNA-Binding Factors, Erythropoiesis, GATA1 Transcription Factor, Helix-Loop-Helix Motifs, Humans, LIM Domain Proteins, Leukemia, Erythroblastic, Acute, Leukemia, T-Cell, Metalloproteins, Proto-Oncogene Proteins, Recombinant Proteins, Transcription Factors, Transcription, Genetic, Transfection, Tumor Cells, Cultured, Zinc Fingers