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Burkitt's lymphoma cells are characterized by the presence of specific chromosomal translocation bringing the immunoglobulin and the c-myc proto-oncogenes into the proximity of each other. Different translocations involve each of the three immunoglobulin loci but the breakpoint with respect to the c-myc gene is shown to be very variable. In t8/14 the breakpoint occurs upstream from the c-myc gene whilst in the variant lymphomas it occurs downstream from the gene. Possible ways in which the translocation affects the c-myc gene are discussed.

Type

Journal article

Journal

J Cell Sci Suppl

Publication Date

1984

Volume

1

Pages

95 - 101

Keywords

Animals, Base Sequence, Burkitt Lymphoma, Chromosomes, Immunoglobulin Heavy Chains, Mice, Models, Genetic, Multiple Myeloma, Oncogenes, Translocation, Genetic