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We previously identified a putative T cell oncogene on chromosome 11 near a translocation t(11;14)(p15;q11) in a human T cell tumour. The gene is transcribed from distinct promoters which have unrelated sequences, which occur within close but distinct methylation-free islands and which allow cell specific production of mRNA. The alternative first exons each contain a protein initiation codon from which two species of protein can be made, differing by only a single amino acid. The protein sequence is highly conserved between man and mouse (98%) and the same single codon difference between alternative first exons is also conserved. This is, therefore, a new form of eukaryotic gene organization from which similar proteins can be made from distinct mRNA species.

Type

Journal article

Journal

EMBO J

Publication Date

03/1990

Volume

9

Pages

857 - 868

Keywords

Amino Acid Sequence, Base Sequence, Chromosomes, Human, Pair 11, Chromosomes, Human, Pair 14, Codon, Exons, Gene Expression, Genomic Library, Humans, Molecular Sequence Data, Neoplasm Proteins, Oligonucleotide Probes, Oncogenes, Promoter Regions, Genetic, RNA, Messenger, Receptors, Antigen, T-Cell, Sequence Homology, Nucleic Acid, Transcription, Genetic, Transfection, Translocation, Genetic