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The T cell receptor alpha chain gene locus and the immunoglobulin heavy chain gene locus (IgH) have previously been mapped to the q11 and q32 positions respectively of the human chromosome 14. Both of these sites are also common breakpoints in lymphocytes from ataxia telangiectasia (A-T) patients. Using in situ hybridisation we show that the 14q32 breakpoint in an A-T non-leukaemic T cell clone with t(14;14) translocation, lies outside the IgH locus and proximal to it with respect to the centromere. The 14q11-14qter segment of the homologous chromosome 14 carrying the constant gene region of the alpha chain locus is translocated to this 14q32 position.

Type

Journal article

Journal

Hum Genet

Publication Date

07/1986

Volume

73

Pages

254 - 259

Keywords

Ataxia Telangiectasia, Burkitt Lymphoma, Chromosome Banding, Chromosome Inversion, Chromosome Mapping, Chromosomes, Human, 13-15, Clone Cells, Genetic Markers, Humans, Karyotyping, Lymphoma, Nucleic Acid Hybridization, Receptors, Antigen, T-Cell, T-Lymphocytes, Translocation, Genetic