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T-cell tumours are frequently found to carry an inversion of chromosome 14 (inv(14)) (q11;q32) or more rarely a chromosome 14 translocation t(14;14) with the same cytogenetic breakpoints (q11;q32). We have examined the molecular junctions of an inv(14) and a translocation t(14;14) using T-cell receptor (TCR) alpha joining (J) region probes. Both of these chromosomal abnormalities have breakpoints within the TCR J alpha locus at 14q11 and both have breakpoints which are proximal (i.e. on the centromeric side) to the immunoglobulin heavy chain JH region at 14q32. The cloned segments corresponding to the junctions at 14q32 are not associated with obvious immunoglobulin-like sequences. This contrasts to the previously described inv(14) in the cell line SUP-T1 and places a potential cluster of chromosome 14 breakpoints downstream of the Ig JH locus. The possible role of the varying breakpoints in the development of these tumours is discussed.

Type

Journal article

Journal

EMBO J

Publication Date

08/1987

Volume

6

Pages

2273 - 2280

Keywords

Amino Acid Sequence, Base Sequence, Chromosome Inversion, Chromosomes, Human, Pair 14, Humans, Immunoglobulin J-Chains, Immunoglobulin Joining Region, Lymphoma, Nucleic Acid Hybridization, T-Lymphocytes, Translocation, Genetic