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The IF2 immunoglobulin mutant is a DNA deletion of one coding segment and large sections of the flanking intervening sequences. The deletion results in a new splicing pattern and starts in a DNA region containing tandemly repeated sequences which may carry heavy-chain class switch signals.

Type

Journal article

Journal

Nature

Publication Date

14/08/1980

Volume

286

Pages

669 - 675

Keywords

Animals, Base Sequence, Chromosome Deletion, DNA, Genes, Heavy Chain Disease, Humans, Immunoglobulin Constant Regions, Immunoglobulin Heavy Chains, Immunoglobulin gamma-Chains, Immunoglobulins, Mice, Mutation, Nucleic Acid Conformation, Nucleic Acid Precursors, RNA, Messenger