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We have shown using in situ hybridization that the constant region of the kappa light chain immunoglobulin gene (Ck) is translocated from chromosome 2 to chromosome 8 in Burkitt's lymphoma cells with a (2;8) translocation. The Ck gene then ends up adjacent to and on the 3' side of c-myc. The breakpoint probably falls between the gene for the variable region of the kappa light chain (Vk) and the Ck gene.


Journal article


Cytogenet Cell Genet

Publication Date





168 - 172


Burkitt Lymphoma, Cell Line, Chromosome Banding, Chromosomes, Human, 1-3, Chromosomes, Human, 6-12 and X, Genes, Humans, Immunoglobulin Light Chains, Immunoglobulin kappa-Chains, Nucleic Acid Hybridization, Oncogenes, Translocation, Genetic