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We have shown using in situ hybridization that the constant region of the kappa light chain immunoglobulin gene (Ck) is translocated from chromosome 2 to chromosome 8 in Burkitt's lymphoma cells with a (2;8) translocation. The Ck gene then ends up adjacent to and on the 3' side of c-myc. The breakpoint probably falls between the gene for the variable region of the kappa light chain (Vk) and the Ck gene.

Type

Journal article

Journal

Cytogenet Cell Genet

Publication Date

1985

Volume

39

Pages

168 - 172

Keywords

Burkitt Lymphoma, Cell Line, Chromosome Banding, Chromosomes, Human, 1-3, Chromosomes, Human, 6-12 and X, Genes, Humans, Immunoglobulin Light Chains, Immunoglobulin kappa-Chains, Nucleic Acid Hybridization, Oncogenes, Translocation, Genetic