Cookies on this website
We use cookies to ensure that we give you the best experience on our website. If you click 'Continue' we'll assume that you are happy to receive all cookies and you won't see this message again. Click 'Find out more' for information on how to change your cookie settings.

The human homeobox gene HOX11 has been identified at the site of a chromosomal translocation in a subset of T-cell acute leukaemias. In the mouse genome, the hox11 family consists of at least three related genes, each of which possesses a highly conserved homeobox. To assist in elucidating the roles of this gene, a homologue was studied from Drosophila melanogaster. This gene, 311, shares similar identity to all three murine family members and contains the threonine residue in helix 3 of the homeodomain characteristic of the Hox11 family. It maps to a cluster of NK-homeobox genes which function in muscle development. Gene 311 exhibits a similar temporal pattern of expression to the NK genes in this cluster. Therefore, 311 may constitute part of a homeobox cluster in which the genes are both co-ordinately regulated and functionally related.

Type

Journal article

Journal

Gene

Publication Date

20/04/1994

Volume

141

Pages

225 - 229

Keywords

Amino Acid Sequence, Animals, Blotting, Northern, Chromosome Mapping, Drosophila melanogaster, Genes, Homeobox, Genes, Insect, Humans, Leukemia-Lymphoma, Adult T-Cell, Mice, Molecular Sequence Data, Multigene Family, RNA, Messenger, Sequence Alignment, Sequence Homology, Amino Acid