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RBTN2 is a LIM domain protein which can be activated by the translocation t(11;14)(p13;q11) in childhood T cell acute leukaemia. Transgenic mice were examined in which rbtn2 protein is expressed in the T cell lineage. An average of 72% of these mice developed T cell tumours before 18 months of age, compared with 9% in transgenic mice expressing the related gene Rbtn-1. Rbtn2-induced tumours first appeared at 5 months of age and were clonal. They displayed a range of phenotypes, the most notable being CD3/CD45R double-positive cells. Tumours expressing either T cell receptor alpha/beta or gamma/delta heterodimers were found. Thus rbtn2 can promote tumours within a range of T cell types and maturities. The latency period before tumour development indicates that secondary events must occur before the onset of overt malignancy.

Type

Journal article

Journal

Oncogene

Publication Date

12/1994

Volume

9

Pages

3675 - 3681

Keywords

Adaptor Proteins, Signal Transducing, Animals, Antigens, CD2, DNA-Binding Proteins, LIM Domain Proteins, Lymphoma, T-Cell, Metalloproteins, Mice, Mice, Transgenic, Neoplasm Invasiveness, Phenotype, Translocation, Genetic