Cookies on this website
We use cookies to ensure that we give you the best experience on our website. If you click 'Continue' we'll assume that you are happy to receive all cookies and you won't see this message again. Click 'Find out more' for information on how to change your cookie settings.

Evidence is presented that the mouse light-chain coding sequence is interrupted in a 27S nuclear RNA species, whereas the sequence is continuous in both a 13S nuclear RNA and in cytoplasmic mRNA. The discontinuity of coding regions in the 27S nuclear RNA parallels the situation found in myeloma DNA and indicates, therefore, that the removal of interruptions in the V and C regions occurs at the level of nuclear RNA.

Type

Journal article

Journal

Nature

Publication Date

28/09/1978

Volume

275

Pages

291 - 296

Keywords

Animals, Antibody-Producing Cells, Binding Sites, Antibody, Cell Line, Genes, Immunoglobulin Constant Regions, Immunoglobulin Heavy Chains, Immunoglobulin Light Chains, Immunoglobulin Variable Region, Immunoglobulins, Mice, Molecular Weight, RNA, Heterogeneous Nuclear, Transcription, Genetic