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A mouse cloned cDNA probe containing a variable (V) region belonging to the VHIII subgroup has been used in filter hybridisations to estimate the number of heavy-chain V-genes in this subgroup of mouse and human DNA. There seem to be about 10 and 20 VH-genes hybridising to this probe in mouse and human DNA, respectively. Studies of cross-hybridisation of the related VK-genes from MOPC21 and MPC11 myelomas indicate that the experiments detect all members of the VHIII subgroup.

Type

Journal article

Journal

Nature

Publication Date

20/03/1980

Volume

284

Pages

238 - 243

Keywords

Animals, Antibody Diversity, Base Sequence, Binding Sites, Antibody, Genes, Humans, Immunoglobulin Heavy Chains, Immunoglobulin Variable Region, Immunoglobulin kappa-Chains, Mice, Nucleic Acid Hybridization, Structure-Activity Relationship