Cookies on this website
We use cookies to ensure that we give you the best experience on our website. If you click 'Continue' we'll assume that you are happy to receive all cookies and you won't see this message again. Click 'Find out more' for information on how to change your cookie settings.

A human T cell lymphoma has been described in which an inversion of chromosome 14 results in fusion of an immunoglobulin heavy chain VH with a T cell receptor J alpha segment, potentially resulting in a chimeric protein with immunoglobulin VH region recognition plus T cell receptor effector functions. Examination of the mRNA species expressed from the IgT gene in this lymphoma shows a variety of forms but all IgT mRNA include the T cell-specific exon, ET, previously located in the distal part of the VH locus. In such mRNA species, the normal leader exon of the Ig VH segment, which encodes most of the hydrophobic signal peptide, is replaced by the short ET exon encoding mainly non-hydrophobic residues. Two forms of this mRNA exist which lack the Ig VH leader sequence and thus potentially yield non-membrane proteins in the T cell lymphoma.

Original publication

DOI

10.1002/eji.1830221042

Type

Journal article

Journal

Eur J Immunol

Publication Date

10/1992

Volume

22

Pages

2745 - 2748

Keywords

Alternative Splicing, Amino Acid Sequence, Base Sequence, Chromosome Inversion, Cloning, Molecular, Exons, Humans, Immunoglobulin Heavy Chains, Immunoglobulin Variable Region, Lymphoma, T-Cell, Molecular Sequence Data, RNA, Messenger, Receptors, Antigen, T-Cell, alpha-beta