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The ectopic expression of LMO1 or LMO2 in T cell acute leukaemias resulting from chromosomal translocations t(11;14)(p15;qll) or t(11;14)(p13;q11) respectively in a causal factor in tumorigenesis. LMO1 has been found as a heterodimer with a 46 Kd protein in a T cell line derived from a childhood T-acute leukaemia. This 46 Kd protein is the LIM-binding protein LDB1/NLI. The latter is a phosphoprotein and binds to LMO1 in its phosphorylated state and essentially all the LMO1 and LDB1 protein in the T cell line is part of the complex. Therefore, the LMO1-LDB1 interaction is likely to be involved in tumorigenesis after LMO1 is ectopically expressed following chromosomal translocation in T cells prior to development of acute leukaemias.

Original publication

DOI

10.1038/sj.onc.1202353

Type

Journal article

Journal

Oncogene

Publication Date

17/12/1998

Volume

17

Pages

3199 - 3202

Keywords

Chromosomes, Human, Pair 11, Chromosomes, Human, Pair 14, DNA-Binding Proteins, Humans, LIM Domain Proteins, Leukemia-Lymphoma, Adult T-Cell, Metalloproteins, Oncogene Proteins, Transcription Factors, Translocation, Genetic, Tumor Cells, Cultured