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Attachment of peroxisomes to cytoskeleton and movement along microtubular filaments and actin cables are essential and highly regulated processes enabling metabolic efficiency, biogenesis, maintenance and inheritance of this dynamic cellular compartment. Several peroxisome-associated proteins have been identified, which mediate interaction with motor proteins, adaptor proteins or other constituents of the cytoskeleton. It appears that there is a species-specific complexity of protein-protein interactions required to control directional movement and arresting. An open question is why some proteins with a specific role in peroxisomal protein import have an additional function in the regulation of cytoskeleton binding and motility of peroxisomes.

Type

Journal article

Journal

Biochimica et biophysica acta

Publication Date

05/2016

Volume

1863

Pages

1019 - 1026

Addresses

Max-Planck-Institute of Biophysics, Frankfurt, Germany.

Keywords

Peroxisomes, Microtubules, Humans, Saccharomyces cerevisiae, Myosin Type V, Myosin Heavy Chains, Saccharomyces cerevisiae Proteins, Membrane Proteins, Protein Isoforms, Receptors, Cytoplasmic and Nuclear, Signal Transduction, Gene Expression Regulation, Biological Transport, Actin Cytoskeleton, Organelle Biogenesis