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Hepatic hormone hepcidin is a principal regulator of iron homeostasis and a pathogenic factor in common iron disorders. Hepcidin deficiency causes iron overload in hereditary hemochromatosis and iron-loading anemias, whereas hepcidin excess causes or contributes to the development of iron-restricted anemia in inflammatory diseases, infections, some cancers, and chronic kidney disease. Because of this, hepcidin may become a useful tool for diagnosis and management of iron disorders. Furthermore, a number of strategies that target hepcidin, its receptor, and its regulators are under development as novel therapeutic approaches for diseases associated with iron dysregulation.

Original publication

DOI

10.1111/ijlh.12358

Type

Journal article

Journal

Int J Lab Hematol

Publication Date

05/2015

Volume

37 Suppl 1

Pages

92 - 98

Keywords

Hepcidin, anemia, ferroportin, iron, iron overload, Anemia, Iron-Deficiency, Animals, Hepcidins, Homeostasis, Humans, Iron, Iron Metabolism Disorders, Molecular Targeted Therapy, Signal Transduction