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Liquid-ordered phases are one of two biochemically active membrane states, which until now were thought to be a unique consequence of the interactions between eukaryotic membrane lipids. The formation of a liquid-ordered phase depends crucially on the ordering properties of sterols. However, it is not known whether this capacity exists in organisms that lack sterols, such as bacteria. We show that diplopterol, the simplest bacterial hopanoid, has similar properties and that hopanoids are bacterial "sterol surrogates" with the ability to order saturated lipids and to form a liquid-ordered phase in model membranes. These observations suggest that the evolution of an ordered biochemically active liquid membrane could have evolved before the oxygenation of Earth's surface and the emergence of sterols.

Original publication

DOI

10.1073/pnas.1212141109

Type

Journal article

Journal

Proc Natl Acad Sci U S A

Publication Date

28/08/2012

Volume

109

Pages

14236 - 14240

Keywords

Bacteria, Cell Membrane, Cholesterol, Evolution, Molecular, Lipid A, Lipid Bilayers, Liposomes, Membrane Lipids, Models, Chemical, Sphingomyelins, Sterols, Terpenes, Triterpenes