Cookies on this website
We use cookies to ensure that we give you the best experience on our website. If you click 'Continue' we'll assume that you are happy to receive all cookies and you won't see this message again. Click 'Find out more' for information on how to change your cookie settings.

The strain diversity of 100 Mycobacterium tuberculosis isolates collected over a period of 18 months from tuberculosis (TB) cases in Sri Lanka was studied by spoligotyping. When compared to the international spoligotyping database, 43 spoligotype patterns were identified, of which 20 were previously described. The majority of isolates (72.45%) were clustered into major genetic group 1, and the most common spoligotype pattern belonged to the Beijing (ST1) strain family. All the Beijing strain isolates belonged to more recently evolved sublineages of M. tuberculosis. The characterization of Sri Lankan M. tuberculosis isolates by spoligotyping shows a heterogeneous pattern. The physical separation from the main Indian peninsula may be responsible for the different patterns observed between the two countries. An in-depth field study is needed to understand the spread and the true epidemiology of this infection.

Original publication

DOI

10.1016/j.trstmh.2008.04.025

Type

Journal article

Journal

Trans R Soc Trop Med Hyg

Publication Date

10/2008

Volume

102

Pages

997 - 1002

Keywords

Adolescent, Adult, Bacterial Typing Techniques, Female, Humans, Male, Middle Aged, Mycobacterium tuberculosis, Oligonucleotides, Sri Lanka, Tuberculosis, Multidrug-Resistant, Tuberculosis, Pulmonary