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Invariant natural killer T (iNKT) cells recognize endogenous and exogenous lipids in the context of CD1d molecules, and through the activation and maturation of dendritic cells and B cells, can significantly enhance priming of antigen-specific T and B cell responses. Recent findings have provided important insights into the recognition of several novel endogenous lipids by iNKT cells, and into the mechanisms controlling their generation and loading onto CD1d molecules. In this review we discuss these latest findings and describe the role of autophagy in iNKT cell development and activation.

Original publication




Journal article


Curr Opin Immunol

Publication Date





116 - 125


Animals, Antigen Presentation, Antigens, CD1d, Autophagy, B-Lymphocytes, Dendritic Cells, Gastrointestinal Microbiome, Humans, Lipids, Natural Killer T-Cells